Detalhe da pesquisa
1.
Identification, structural, and biophysical characterization of a positive modulator of human Kv3.1 channels.
Proc Natl Acad Sci U S A
; 120(42): e2220029120, 2023 10 17.
Artigo
Inglês
| MEDLINE | ID: mdl-37812700
2.
A streamlined, automated workflow to screen and triage large numbers of baculoviruses for protein expression.
Protein Expr Purif
; 215: 106406, 2024 Mar.
Artigo
Inglês
| MEDLINE | ID: mdl-37995943
3.
The pharmacologic and toxicologic characterization of the potent and selective KRAS G12D inhibitors ERAS-4693 and ERAS-5024.
Toxicol Appl Pharmacol
; 474: 116601, 2023 09 01.
Artigo
Inglês
| MEDLINE | ID: mdl-37321326
4.
Development of a robust crystallization platform for immune receptor TREM2 using a crystallization chaperone strategy.
Protein Expr Purif
; 179: 105796, 2021 03.
Artigo
Inglês
| MEDLINE | ID: mdl-33221505
5.
Resensitization to Crizotinib by the Lorlatinib ALK Resistance Mutation L1198F.
N Engl J Med
; 374(1): 54-61, 2016 Jan 07.
Artigo
Inglês
| MEDLINE | ID: mdl-26698910
6.
PF-06463922 is a potent and selective next-generation ROS1/ALK inhibitor capable of blocking crizotinib-resistant ROS1 mutations.
Proc Natl Acad Sci U S A
; 112(11): 3493-8, 2015 Mar 17.
Artigo
Inglês
| MEDLINE | ID: mdl-25733882
7.
Acquired resistance to crizotinib from a mutation in CD74-ROS1.
N Engl J Med
; 368(25): 2395-401, 2013 Jun 20.
Artigo
Inglês
| MEDLINE | ID: mdl-23724914
8.
Structure-Based Design and Synthesis of Potent and Selective KRAS G12D Inhibitors.
ACS Med Chem Lett
; 14(10): 1351-1357, 2023 Oct 12.
Artigo
Inglês
| MEDLINE | ID: mdl-37849557
9.
SAM-Competitive PRMT5 Inhibitor PF-06939999 Demonstrates Antitumor Activity in Splicing Dysregulated NSCLC with Decreased Liability of Drug Resistance.
Mol Cancer Ther
; 21(1): 3-15, 2022 01.
Artigo
Inglês
| MEDLINE | ID: mdl-34737197
10.
Structures of active-state orexin receptor 2 rationalize peptide and small-molecule agonist recognition and receptor activation.
Nat Commun
; 12(1): 815, 2021 02 05.
Artigo
Inglês
| MEDLINE | ID: mdl-33547286
11.
Structure-Based Drug Design and Synthesis of PI3Kα-Selective Inhibitor (PF-06843195).
J Med Chem
; 64(1): 644-661, 2021 01 14.
Artigo
Inglês
| MEDLINE | ID: mdl-33356246
12.
Structure and thermodynamic characterization of the EphB4/Ephrin-B2 antagonist peptide complex reveals the determinants for receptor specificity.
Structure
; 14(2): 321-30, 2006 Feb.
Artigo
Inglês
| MEDLINE | ID: mdl-16472751
13.
Reviving B-Factors: Retrospective Normalized B-Factor Analysis of c-ros Oncogene 1 Receptor Tyrosine Kinase and Anaplastic Lymphoma Kinase L1196M with Crizotinib and Lorlatinib.
ACS Med Chem Lett
; 9(9): 878-883, 2018 Sep 13.
Artigo
Inglês
| MEDLINE | ID: mdl-30258534
14.
Reviving B-Factors: Activating ALK Mutations Increase Protein Dynamics of the Unphosphorylated Kinase.
ACS Med Chem Lett
; 9(9): 872-877, 2018 Sep 13.
Artigo
Inglês
| MEDLINE | ID: mdl-30258533
15.
Optimization of Orally Bioavailable Enhancer of Zeste Homolog 2 (EZH2) Inhibitors Using Ligand and Property-Based Design Strategies: Identification of Development Candidate (R)-5,8-Dichloro-7-(methoxy(oxetan-3-yl)methyl)-2-((4-methoxy-6-methyl-2-oxo-1,2-dihydropyridin-3-yl)methyl)-3,4-dihydroisoquinolin-1(2H)-one (PF-06821497).
J Med Chem
; 61(3): 650-665, 2018 02 08.
Artigo
Inglês
| MEDLINE | ID: mdl-29211475
16.
Conserved RNA-binding specificity of polycomb repressive complex 2 is achieved by dispersed amino acid patches in EZH2.
Elife
; 62017 11 29.
Artigo
Inglês
| MEDLINE | ID: mdl-29185984
17.
Polycomb repressive complex 2 structure with inhibitor reveals a mechanism of activation and drug resistance.
Nat Commun
; 7: 11384, 2016 04 28.
Artigo
Inglês
| MEDLINE | ID: mdl-27122193
18.
Comparison of a High-Throughput Mass Spectrometry Method and Radioactive Filter Binding to Assay the Protein Methyltransferase PRMT5.
Assay Drug Dev Technol
; 13(4): 235-40, 2015 May.
Artigo
Inglês
| MEDLINE | ID: mdl-26065559
19.
Engineering of an isolated p110α subunit of PI3Kα permits crystallization and provides a platform for structure-based drug design.
Protein Sci
; 23(10): 1332-40, 2014 Oct.
Artigo
Inglês
| MEDLINE | ID: mdl-25043846
20.
Enzyme kinetics and distinct modulation of the protein kinase N family of kinases by lipid activators and small molecule inhibitors.
Biosci Rep
; 34(2)2014 04 01.
Artigo
Inglês
| MEDLINE | ID: mdl-27919031